Seed-stage

Breathe in Breakthroughs

Developing a novel, inhaled, small molecule therapy to reduce severe asthma exacerbations. A targeted, safer approach to help patients breathe easier.

Deep respiratory biology
Inhaled formulation expertise
Speed to clinical proof of concept
Our Mission

A Targeted, Inhaled Approach to Severe Asthma

Despite optimized care, breakthrough exacerbations drive morbidity, mortality, and healthcare utilization. Current biologics target primarily the Th2 pathway, leaving many patients without adequate relief.

Parteo Therapeutics is developing an inhaled small molecule that targets mast cells, the upstream driver of asthma exacerbations, directly in the lung. By focalizing therapy where it matters most, we aim to deliver superior efficacy with an improved safety profile.

Mast cell signaling diagram showing allergen cross-linking, c-kit/SCF interaction, cytokine release, and Th2 cell activation in airway epithelium
Our Approach

From Discovery to Proof-of-Concept

Design

Leverage existing clinical-stage mast cell targeted chemical matter to design around scaffolds with demonstrated activity

Reformulate

Rapidly reformulate for inhaled delivery to focalize drug in the lung

De-risk

Confirm preferential lung delivery, tolerability and preclinical efficacy to validate the approach

Prove

Rapid Proof-of-Concept via inhaled allergen bronchoprovocation clinical trial

Leadership

Experienced Team in Respiratory Drug Development

JulieAnne Smith
JulieAnne Smith
Founder

CEO, global leadership and operations driving strategy from concept to clinical development to commercialization.

Eric Meltzer, MD
Eric Meltzer, MD
Founder

CMO, physician scientist with deep expertise in respiratory medicine and clinical trial design for inhaled therapeutics.

Frank Koppenhagen, PhD
Frank Koppenhagen, PhD
Founder

Veteran biotech leader and aerosol expert specializing in inhaled drug formulation and device development.

Get in Touch

Partner With Us

Interested in learning more about Parteo Therapeutics and our inhaled mast cell targeted inhibitor program? We welcome conversations with potential partners and investors.